TB47

TESTED COMPOUNDS 

TB47

INHIBITORY CONCENTRATION VALUES (MIC/IC50) 

MIC = 0.2 - 0.4µg/ml and > 50µg/ml

EXPERIMENTAL TECHNIQUE 

in vitro & in vivo

LINK TO PUBMED 

https://pubmed.ncbi.nlm.nih.gov/30705268/

https://pubmed.ncbi.nlm.nih.gov/33777679/

MOLECULAR FORMULA 

C29H29F3N4O3

2D STRUCTURE

2D Structure of TB47

MOLECULAR WEIGHT 

538.571 µg/mol

PUBCHEM CID 

122188597

DRUG BANK ID 

DB05474

REFERENCE 

Liu, Y., Gao, Y., Liu, J., Tan, Y., Liu, Z., Chhotaray, C., Jiang, H., Lu, Z., Chiwala, G., Wang, S., Makafe, G., Islam, M. M., Hameed, H. M. A., Cai, X., Wang, C., Li, X., Tan, S., & Zhang, T. (2019). The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model. Nature Communications, 10(1). https://doi.org/10.1038/S41467-019-08464-Y

Gaoa, Y., Hameed, H. M. A., Liua, Y., Guoa, L., Fanga, C., Tiana, X., Liua, Z., Wanga, S., Lua, Z., Islama, M. M., & Zhang, T. (2021). Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans. Acta Pharmaceutica Sinica. B, 11(3), 738?749. https://doi.org/10.1016/J.APSB.2020.11.007