EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS
Pretomanid (PA-824)
CLASS
Nitroimidazopyran
MECHANISM OF ACTION
Bactericidal activity
DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)
Experimental
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/32310683/
SIMILAR TARGETS IN OTHER SPECIES
Fatty acid synthetase ~ Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
DRUG BANK ID
DB05154
EXTERNAL LINKS
PubChem Compound 456199 PubChem Substance 175426953 ChemSpider 401693 BindingDB 50363237 RxNav 2198359 ChEMBL CHEMBL227875 ZINC ZINC000003821675 Wikipedia Pretomanid
REFERENCE
Diacon, A. H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P. R., Van Niekerk, C., Everitt, D., Hutchings, J., Burger, D. A., Schall, R., & Mendel, C. M. (2015). Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. American Journal of Respiratory and Critical Care Medicine, 191(8), 943–953. https://doi.org/10.1164/RCCM.201410-1801OC