EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS
Bedaquiline
CLASS
Diarylquinoline
MECHANISM OF ACTION
Bactericidal activity
DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)
Experimental
MODE OF ADMINISTRATION
Oral
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/27755552/
SIMILAR TARGETS IN OTHER SPECIES
ATP synthase subunit c ~ Mycobacterium tuberculosis
DRUG BANK ID
DB08903
EXTERNAL LINKS
KEGG Drug D09872 PubChem Compound 5388906 PubChem Substance 175427143 ChemSpider 4534966 BindingDB 50063995 RxNav 1364504 ChEBI 72292 ChEMBL CHEMBL376488 ZINC ZINC000004655029 RxList RxList Drug Page http://www.rxlist.com/sirturo-drug.htm Wikipedia Bedaquiline
REFERENCE
Aure ?lie, C., Je ?ro?me, R., Nicolas, V., Alexandra, A., & Vincent, J. (2016). Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium ulcerans Infection in Mice. PLoS Neglected Tropical Diseases, 10(10). https://doi.org/10.1371/JOURNAL.PNTD.0005066