EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS
Clofazimine
CLASS
Riminophenazine
MECHANISM OF ACTION
Bactericidal activity
DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)
Experimental
MODE OF ADMINISTRATION
Oral
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/26042792/
SIMILAR TARGETS IN OTHER SPECIES
Peroxisome proliferator-activated receptor gamma ~ Humans
DRUG BANK ID
DB00845
EXTERNAL LINKS
KEGG Drug D00278 KEGG Compound C06915 PubChem Compound 2794 PubChem Substance 46508174 ChemSpider 2692 BindingDB 50378783 RxNav 2592 ChEBI 3749 ChEMBL CHEMBL1292 ZINC ZINC000100037101 Drugs.com Drugs.com Drug Page https://www.drugs.com/cons/clofazimine.html Wikipedia Clofazimine
REFERENCE
Converse, P. J., Tyagi, S., Xing, Y., Li, S.-Y., Kishi, Y., Adamson, J., Nuermberger, E. L., & Grosset, J. H. (2015). Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. PLoS Neglected Tropical Diseases, 9(6). https://doi.org/10.1371/JOURNAL.PNTD.0003823