EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS
Milbemycin oxime and selamectin
CLASS
Avermectins and milbemycins
MECHANISM OF ACTION
Bactericidal activity (in vitro pharmacodynamic studies demonstrates exposure-dependent activity of selamectin)
DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)
Experimental
MODE OF ADMINISTRATION
Oral
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/26270480/
SIMILAR TARGETS IN OTHER SPECIES
Cytochrome P450 3A4 ~ Human
DRUG BANK ID
DB11531 DB11459
EXTERNAL LINKS
ChemSpider 16738655 RxNav 1044269 ChEMBL CHEMBL1908325 ZINC ZINC000169677006 Wikipedia Selamectin
REFERENCE
Scherr, N., Pluschke, G., Thompson, C. J., & Ram?n-Garc?a, S. (2015). Selamectin is the avermectin with the best potential for Buruli ulcer treatment. In PLoS Neglected Tropical Diseases (Vol. 9, Issue 8). https://doi.org/10.1371/journal.pntd.0003996