Prulifloxacin

EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS

Prulifloxacin

---

CLASS

Quinolone

---

TARGET PROTEIN

DNA gyrase

---

MECHANISM OF ACTION

Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA)

---

DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)

Experimental

---

MODE OF ADMINISTRATION

Oral

---

LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/32091697/                                                                                                                        

https://pubmed.ncbi.nlm.nih.gov/26883701/

---

DRUG BANK ID

DB11892

---

EXTERNAL LINKS

PubChem Compound 65947

PubChem Substance 347828227

ChemSpider 59351

ChEBI 32071

ChEMBL CHEMBL422648

Wikipedia Prulifloxacin

---

REFERENCE

Scherr, N., Pluschke, G., Thompson, C. J., & Ram?n-Garc?a, S. (2015). Selamectin is the avermectin with the best potential for Buruli ulcer treatment. In PLoS Neglected Tropical Diseases (Vol. 9, Issue 8). https://doi.org/10.1371/journal.pntd.0003996

---