Ofloxacin

EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS

Ofloxacin

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CLASS

Quinolone

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TARGET PROTEIN

DNA gyrase

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MECHANISM OF ACTION

Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA)

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DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)

Experimental

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MODE OF ADMINISTRATION

Oral

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/32091697/ 

https://pubmed.ncbi.nlm.nih.gov/10660507/

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SIMILAR TARGETS IN OTHER SPECIES

DNA gyrase subunit A ~ Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

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DRUG BANK ID

DB01165

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EXTERNAL LINKS

Human Metabolome Database HMDB0015296

KEGG Drug D00453

KEGG Compound C07321

PubChem Compound 4583

PubChem Substance 46507574

ChemSpider 4422

BindingDB 50045004

RxNav 7623

ChEBI 7731

ChEMBL CHEMBL4

Drugs.com Drugs.com Drug Page  https://www.drugs.com/cdi/ofloxacin-drops.html

PDRhealth PDRhealth Drug Page http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/flo1181.shtml

Wikipedia Ofloxacin

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REFERENCE

Thangaraj, H. S., Adjeib, O., Allen, B. W., Portaels, F., Evans, M. R. W., Banerjee, D. K., & Wansbrough-Jonesa, M. H. (2000). In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans. The Journal of Antimicrobial Chemotherapy, 45(2), 231?233. https://doi.org/10.1093/JAC/45.2.231



Pluschke, G., & R?ltgen, K. (2019). Buruli ulcer: Mycobacterium ulcerans disease. In Buruli Ulcer: Mycobacterium ulcerans Disease. https://doi.org/10.1007/978-3-030-11114-4

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