Ciprofloxacin

EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS

Ciprofloxacin

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CLASS

Fluoroquinolones

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TARGET PROTEIN

DNA gyrase-catalyzed super-coiling of double-stranded DNA

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MECHANISM OF ACTION

Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA)

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DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)

Investigational

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MODE OF ADMINISTRATION

Oral

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/32091697/ 

https://pubmed.ncbi.nlm.nih.gov/10660507/

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SIMILAR TARGETS IN OTHER SPECIES

Bacterial DNA gyrase (topoisomerase II) ~ Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

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DRUG BANK ID

DB00537

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EXTERNAL LINKS

Human Metabolome Database HMDB0014677

KEGG Drug D00186

KEGG Compound C05349

PubChem Compound 2764

PubChem Substance 46504733

ChemSpider 2662

BindingDB 21690

RxNav 2551

ChEBI 100241

ChEMBL CHEMBL8

ZINC ZINC000000020220

Drugs.com Drugs.com Drug Page  https://www.drugs.com/cdi/ciprofloxacin-drops.html

PDRhealth PDRhealth Drug Page  http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cip1082.shtml

Wikipedia Ciprofloxacin

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REFERENCE

Thangaraj, H. S., Adjeib, O., Allen, B. W., Portaels, F., Evans, M. R. W., Banerjee, D. K., & Wansbrough-Jonesa, M. H. (2000). In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans. The Journal of Antimicrobial Chemotherapy, 45(2), 231?233. https://doi.org/10.1093/JAC/45.2.231



Pluschke, G., & R?ltgen, K. (2019). Buruli ulcer: Mycobacterium ulcerans disease. In Buruli Ulcer: Mycobacterium ulcerans Disease. https://doi.org/10.1007/978-3-030-11114-4

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