Linezolid

EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS

Linezolid

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CLASS

Oxazolidinone

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MECHANISM OF ACTION

Bactericidal action

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DRUG INTERACTION PHASE (APPROVED, INVESTIGATIONAL, EXPERIMENTAL)

Experimental

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MODE OF ADMINISTRATION

Orally or by IV infusion

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/32091697/                                                                                   

https://pubmed.ncbi.nlm.nih.gov/16723546/

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SIMILAR TARGETS IN OTHER SPECIES

23S ribosomal RNA ~ Enteric bacteria and other eubacteria

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DRUG BANK ID

DB00601

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EXTERNAL LINKS

Human Metabolome Database HMDB0014739

KEGG Drug D00947

KEGG Compound C08146

PubChem Compound 441401

PubChem Substance 46504452

ChemSpider 390139

BindingDB 50116067

RxNav 190376

ChEBI 63607

ChEMBL CHEMBL126

ZINC ZINC000002008866

Drugs.com Drugs.com Drug Page  https://www.drugs.com/cdi/linezolid.html

PDRhealth PDRhealth Drug Page http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/zyv1556.shtml

Wikipedia Linezolid

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REFERENCE

Ji, B., Lefrancois, S., Robert, J., Chauffour, A., Truffot, C., & Jarlier, V. (2006). In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulcerans. Antimicrobial Agents and Chemotherapy, 50(6), 1921?1926. https://doi.org/10.1128/AAC.00052-06



Pluschke, G., & R?ltgen, K. (2019). Buruli ulcer: Mycobacterium ulcerans disease. In Buruli Ulcer: Mycobacterium ulcerans Disease. https://doi.org/10.1007/978-3-030-11114-4

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