GENE NAME
Anthranilate synthase component I
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
trpE
GENE ID
4552112
TDR TARGET ID
954582
PROTEIN LENGTH
512
ASSOCIATED METABOLIC PATHWAYS
Phenylalanine, tyrosine and tryptophan biosynthesis
FUNCTION
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
UNIPROT ID
A0PP26
STRING
362242.MUL_1589
KEGG PATHWAY
mul:MUL_1589
GO - MOLECULAR FUNCTION
GO:0004049 GO:0046872
GO - BIOLOGICAL PROCESS
GO:0000162
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a