GENE NAME
Chorismate synthase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
aroC
TDR TARGET ID
954695
PROTEIN LENGTH
407
ASSOCIATED METABOLIC PATHWAYS
Phenylalanine, tyrosine and tryptophan biosynthesis
FUNCTION
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
UNIPROT ID
A0PPH0
STRING
362242.MUL_1759
KEGG PATHWAY
mul:MUL_1759
GO - MOLECULAR FUNCTION
GO:0004107
GO - BIOLOGICAL PROCESS
GO:0009073 GO:0008652 GO:0009423
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a