Imidazole glycerol phosphate synthase subunit

GENE NAME

Imidazole glycerol phosphate synthase subunit

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ORGANISM

Mycobacterium ulcerans (strain Agy99)

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GENE NAME

hisH

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GENE ID

4552311

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TDR TARGET ID

955227

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PROTEIN LENGTH

201

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ASSOCIATED METABOLIC PATHWAYS

Histidine metabolism

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FUNCTION

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

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UNIPROT ID

A0PP17

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STRING

362242.MUL_1575

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KEGG PATHWAY

mul:MUL_1575

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GO - MOLECULAR FUNCTION

GO:0004359

GO:0000107

GO:0016829

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GO - BIOLOGICAL PROCESS

GO:0006541

GO:0000105

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/22912793/

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REFERENCE

Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a

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