GENE NAME
Imidazole glycerol phosphate synthase subunit
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
hisF
GENE ID
4552314
TDR TARGET ID
952797
PROTEIN LENGTH
261
ASSOCIATED METABOLIC PATHWAYS
Histidine metabolism
FUNCTION
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
UNIPROT ID
A0PP20
STRING
362242.MUL_1578
KEGG PATHWAY
mul:MUL_1578
GO - MOLECULAR FUNCTION
GO:0000107 GO:0016829
GO - BIOLOGICAL PROCESS
GO:0000105
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a