GENE NAME
ketol-acid reductoisomerase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
ilvC
GENE ID
4551257
TDR TARGET ID
953094
PROTEIN LENGTH
333
ASSOCIATED METABOLIC PATHWAYS
Valine, leucine and isoleucine biosynthesis, Pantothenate and CoA biosynthesis
FUNCTION
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UNIPROT ID
A0PPY3
STRING
362242.MUL_1949
KEGG PATHWAY
mul:MUL_1949
GO - MOLECULAR FUNCTION
GO:0004455 GO:0000287 GO:0050661
GO - BIOLOGICAL PROCESS
GO:0009097 GO:0009099
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a