Homoserine dehydrogenase

GENE NAME

Homoserine dehydrogenase

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ORGANISM

Mycobacterium ulcerans (strain Agy99)

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GENE NAME

thrA

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GENE ID

4551394

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TDR TARGET ID

952581

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PROTEIN LENGTH

441

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ASSOCIATED METABOLIC PATHWAYS

Glycine, serine and threonine metabolism, Cysteine and methionine metabolism and Lysine biosynthesis

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FUNCTION

catalyzes the reaction of aspartate-semialdehyde (ASA) to homoserine. The overall reaction reduces the C4 carboxylic acid functional group of ASA to a primary alcohol and oxidizes the C1 aldehyde to a carboxylic acid.

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UNIPROT ID

A0PUL6

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STRING

362242.MUL_3970

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KEGG PATHWAY

mul:MUL_3970

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GO - MOLECULAR FUNCTION

GO:0004412

GO:0050661

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GO - BIOLOGICAL PROCESS

GO:0009097

GO:0009086

GO:0009088

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/22912793/

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REFERENCE

Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a

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