GENE NAME
FAD-dependent thymidylate synthase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
thyX
GENE ID
4550652
TDR TARGET ID
953722
PROTEIN LENGTH
253
ASSOCIATED METABOLIC PATHWAYS
Pyrimidine metabolism and One carbon pool by folate
FUNCTION
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH2 as the reductant.
UNIPROT ID
A0PQH0
STRING
362242.MUL_2183
KEGG PATHWAY
mul:MUL_2183
GO - MOLECULAR FUNCTION
GO:0050660 GO:0050797
GO - BIOLOGICAL PROCESS
GO:0006231 GO:0006235 GO:0032259
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a