GENE NAME
3-oxoacyl-[acyl-carrier-protein] synthase III
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
fabH_1
GENE ID
4553928
TDR TARGET ID
955685
PROTEIN LENGTH
333
ASSOCIATED METABOLIC PATHWAYS
Fatty acid biosynthesis
FUNCTION
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
UNIPROT ID
A0PTL2
STRING
362242.MUL_3531
KEGG PATHWAY
mul:MUL_3531
GO - MOLECULAR FUNCTION
GO:0004315
GO - BIOLOGICAL PROCESS
GO:0006633
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a