GENE NAME
Isocitrate lyase/ isocitrase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
icl
GENE ID
4549819
TDR TARGET ID
954656
PROTEIN LENGTH
428
ASSOCIATED METABOLIC PATHWAYS
Glyoxylate cycle
FUNCTION
The key enzyme of mycobacterium’s glyoxylate. This metabolic pathway enables the organism to make direct use of the intermediates of the tricarboxylic acid (TCA) cycle for gluconeogenesis and other biosynthetic processes essential for its survival and persistence
UNIPROT ID
A0PVX3
STRING
362242.MUL_4536
KEGG PATHWAY
mul:MUL_4536
GO - MOLECULAR FUNCTION
GO:0004451 GO:0046872
GO - BIOLOGICAL PROCESS
GO:0019752
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/29954088/
REFERENCE
Kwofie, S. K., Dankwa, B., Odame, E. A., Agamah, F. E., Doe, L. P. A., Teye, J., Agyapong, O., Miller, W. A., Mosi, L., & Wilson, M. D. (2018b). In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa. Molecules 2018, Vol. 23, Page 1550, 23(7), 1550. https://doi.org/10.3390/MOLECULES23071550