GENE NAME
Putative deoxyribonucleotide triphosphate pyrophosphatase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
MUL_3906
GENE ID
4553722
TDR TARGET ID
952902
PROTEIN LENGTH
204
ASSOCIATED METABOLIC PATHWAYS
Purine metabolism and Thiamine metabolism
FUNCTION
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
UNIPROT ID
A0PUF8
STRING
362242.MUL_3906
KEGG PATHWAY
mul:MUL_3906
GO - MOLECULAR FUNCTION
GO:0035870 GO:0036220 GO:0046872 GO:0017111 GO:0000166 GO:0036222
GO - BIOLOGICAL PROCESS
GO:0009117 GO:0009146
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a