GENE NAME
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexeNe-1-carboxylate synthase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
menD
GENE ID
4551818
TDR TARGET ID
954868
PROTEIN LENGTH
548
ASSOCIATED METABOLIC PATHWAYS
Ubiquinone and other terpenoid-quinone biosynthesis
FUNCTION
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
UNIPROT ID
A0PLU9
STRING
362242.MUL_0654
KEGG PATHWAY
mul:MUL_0654
GO - MOLECULAR FUNCTION
GO:0070204 GO:0000287 GO:0030145 GO:0030976
GO - BIOLOGICAL PROCESS
GO:0009234
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a