GENE NAME
Nitrogen regulatory protein P-II
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
glnB
GENE ID
4551087
TDR TARGET ID
952045
PROTEIN LENGTH
112
ASSOCIATED METABOLIC PATHWAYS
Two-component system
FUNCTION
P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme.
UNIPROT ID
A0PQ53
STRING
362242.MUL_2036
KEGG PATHWAY
mul:MUL_2036
GO - MOLECULAR FUNCTION
GO:0030234
GO - BIOLOGICAL PROCESS
GO:0006808
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a