GENE NAME
Chromosomal replication initiation protein
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
dnaA
GENE ID
4553245
TDR TARGET ID
955150
PROTEIN LENGTH
510
ASSOCIATED METABOLIC PATHWAYS
Two-component system
FUNCTION
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
UNIPROT ID
A0PKB2
STRING
362242.MUL_0001
KEGG PATHWAY
mul:MUL_0001
GO - MOLECULAR FUNCTION
GO:0005524 GO:0003688
GO - BIOLOGICAL PROCESS
GO:0006270 GO:0006275
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a