GENE NAME
2-isopropylmalate synthase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
leuA
GENE ID
4551109
TDR TARGET ID
954605
PROTEIN LENGTH
566
ASSOCIATED METABOLIC PATHWAYS
Valine, leucine and isoleucine biosynthesis and Pyruvate metabolism
FUNCTION
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
UNIPROT ID
A0PVE6
STRING
362242.MUL_4300
KEGG PATHWAY
mul:MUL_4300
GO - MOLECULAR FUNCTION
GO:0003852 GO:0009082
GO - BIOLOGICAL PROCESS
GO:0009098
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a