Holliday junction DNA helicase

GENE NAME

Holliday junction DNA helicase

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ORGANISM

Mycobacterium ulcerans (strain Agy99)

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GENE NAME

ruvA

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GENE ID

4551864

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TDR TARGET ID

951700

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PROTEIN LENGTH

197

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ASSOCIATED METABOLIC PATHWAYS

Homologous recombination

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FUNCTION

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

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UNIPROT ID

A0PPD2

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STRING

362242.MUL_1715

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KEGG PATHWAY

mul:MUL_1715

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GO - MOLECULAR FUNCTION

GO:0005524

GO:0016887

GO:0003677

GO:0009378

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GO - BIOLOGICAL PROCESS

GO:0006310

GO:0006281

GO:0009432

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/22912793/

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REFERENCE

Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a

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