Transcription-repair coupling factor

GENE NAME

Transcription-repair coupling factor

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ORGANISM

Mycobacterium ulcerans (strain Agy99)

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GENE NAME

mfd

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GENE ID

4550805

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TDR TARGET ID

952846

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PROTEIN LENGTH

1222

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ASSOCIATED METABOLIC PATHWAYS

Nucleotide excision repair

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FUNCTION

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.

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UNIPROT ID

A0PW58

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STRING

362242.MUL_4634

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KEGG PATHWAY

mul:MUL_4634

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GO - MOLECULAR FUNCTION

GO:0005524

GO:0003684

GO:0016787

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GO - BIOLOGICAL PROCESS

GO:0006355

GO:0000716

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/22912793/

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REFERENCE

Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a

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