GENE NAME
Preprotein translocase subunit
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
secY
GENE ID
4550180
TDR TARGET ID
951565
PROTEIN LENGTH
441
ASSOCIATED METABOLIC PATHWAYS
Protein export and Bacterial secretion system
FUNCTION
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
UNIPROT ID
A0PM97
STRING
362242.MUL_0828
KEGG PATHWAY
mul:MUL_0828
GO - BIOLOGICAL PROCESS
GO:0065002 GO:0006605 GO:0043952
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a