Bifunctional N-acetylglucosamiNe-1-phosphate

GENE NAME

Bifunctional N-acetylglucosamiNe-1-phosphate

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ORGANISM

Mycobacterium ulcerans (strain Agy99)

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GENE NAME

glmU

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GENE ID

4550808

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TDR TARGET ID

952932

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PROTEIN LENGTH

492

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ASSOCIATED METABOLIC PATHWAYS

Amino sugar and nucleotide sugar metabolism

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FUNCTION

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.

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UNIPROT ID

A0PW60

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STRING

362242.MUL_4637

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KEGG PATHWAY

mul:MUL_4637

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GO - MOLECULAR FUNCTION

GO:0019134

GO:0000287

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GO - BIOLOGICAL PROCESS

GO:0000902

GO:0071555

GO:0009245

GO:0009252

GO:0008360

GO:0006048

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LINK TO PUBMED

https://pubmed.ncbi.nlm.nih.gov/22912793/

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REFERENCE

Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a

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