GENE NAME
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
ispH
GENE ID
4552689
TDR TARGET ID
954756
PROTEIN LENGTH
332
ASSOCIATED METABOLIC PATHWAYS
Terpenoid backbone biosynthesis
FUNCTION
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
UNIPROT ID
A0PKQ3
STRING
362242.MUL_0168
KEGG PATHWAY
mul:MUL_0168
GO - MOLECULAR FUNCTION
GO:0051745 GO:0051539 GO:0046872
GO - BIOLOGICAL PROCESS
GO:0050992 GO:0019288 GO:0016114
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a