GENE NAME
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
ispF
GENE ID
4551861
TDR TARGET ID
955134
PROTEIN LENGTH
159
ASSOCIATED METABOLIC PATHWAYS
Terpenoid backbone biosynthesis
FUNCTION
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
UNIPROT ID
A0PV28
STRING
362242.MUL_4157
KEGG PATHWAY
mul:MUL_4157
GO - MOLECULAR FUNCTION
GO:0008685 GO:0046872
GO - BIOLOGICAL PROCESS
GO:0019288 GO:0016114
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a