GENE NAME
Alpha, alpha-trehalose-phosphate synthase [UDP-forming]
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
otsA
GENE ID
4550106
TDR TARGET ID
951926
PROTEIN LENGTH
500
ASSOCIATED METABOLIC PATHWAYS
Starch and sucrose metabolism
FUNCTION
Probably involved in the osmoprotection via the biosynthesis of trehalose and in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Probably also able to use ADP-Glc, CDP-Glc, GDP-Glc and TDP-Glc as glucosyl donors.
UNIPROT ID
A0PUT6
STRING
362242.MUL_4052
KEGG PATHWAY
mul:MUL_4052
GO - MOLECULAR FUNCTION
GO:0047260 GO:0003825
GO - BIOLOGICAL PROCESS
GO:0003825 GO:0005992
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a