GENE NAME
Dihydrofolate reductase
ORGANISM
Mycobacterium ulcerans (strain Agy99)
GENE NAME
dfrA
GENE ID
4550648
TDR TARGET ID
953668
PROTEIN LENGTH
165
ASSOCIATED METABOLIC PATHWAYS
One carbon pool by folate and Folate biosynthesis
FUNCTION
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
UNIPROT ID
A0PQG8
STRING
362242.MUL_2179
KEGG PATHWAY
mul:MUL_2179
GO - MOLECULAR FUNCTION
GO:0004146 GO:0050661
GO - BIOLOGICAL PROCESS
GO:0006545 GO:0006730 GO:0046654
LINK TO PUBMED
https://pubmed.ncbi.nlm.nih.gov/22912793/
REFERENCE
Butt, A. M., Nasrullah, I., Tahir, S., & Tong, Y. (2012). Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genesand Therapeutic Candidates.pdf (p. 16). https://doi.org/10.1371/annotation/8ce51727-91b0-463f-9b4c-768aab0a230a