|
Clarithromycin
|
Macrolides |
23S rRNA on the 50s ribosomal subunit |
Bactericidal or bacteriostatic activity (It reversibly binds to the 23S rRNA on the 50s ribosomal subunit and subsequently prevents polypeptide synthesis) |
Oral |
|
Rifampicin
|
Rifamycin |
RNA synthesis through interfering with bacterial RNA-polymerase |
Bactericidal activity (act on mycobacteria by inhibiting RNA synthesis through interfering with bacterial RNA-polymerase) |
Oral |
|
Streptomycin
|
Aminoglycoside |
hinders formyl-methionyl-tRNA to bind with bacterial ribosomal 30S subunit |
Bactericidal effect or Bacteriostatic (It is a protein synthesis inhibitor that hinders binding of formyl-methionyl-tRNA to the bacterial ribosomal 30S subunit) |
Injectable |
|
Rifabutin
|
Rifamycin |
RNA synthesis through interfering with bacterial RNA-polymerase |
Bactericidal (act on mycobacteria by inhibiting RNA synthesis through interfering with bacterial RNA-polymerase) |
Oral |
|
Amikacin
|
Aminoglycoside |
formyl-methionyl-tRNA |
Bactericidal activity (It is a protein synthesis inhibitor that hinders binding of formyl-methionyl-tRNA to the bacterial ribosomal 30S subunit) |
Injectable |
|
Azithromycin
|
Macrolide |
|
Bacteriostatic activity |
Oral |
|
Ethambutol
|
Antimycobacterial antibiotics |
|
Bacteriostatic |
Oral |
|
Isoniazid (isonicotinic acid hydrazide [INH])
|
Hydrazide derivatives |
|
Bactericidal activity |
Oral |
|
Kanamycin
|
Aminoglycoside |
|
Bactericidal effect |
Injectable |
|
Erythromycin
|
Macrolides |
|
Bacteriostatic |
Oral |
|
Roxithromycin
|
Macrolides |
|
Bacteriostatic |
Oral |
|
Linezolid
|
Oxazolidinone |
|
Bactericidal action |
Orally or by IV infusion |
|
Posizolid
|
Oxazolidinone |
|
Bactericidal action |
|
|
Sutezolid
|
Oxazolidinone |
|
|
|
|
TB47 (pyrazolo[1,5-a]pyridine-3-carboxamides)
|
Imidazopyridine amide |
QcrB Cytochrome bc1:aa3 |
Bactericidal ctivity (can block the cytochrome bc1 complex, thereby causing a reduction of intracellular ATP and eventually inhibiting the growth of M. ulcerans) |
Oral |
|
P218
|
Synthetic organic |
The enzyme dihydrofolate reductase (DHFR) |
Bactericidal ctivity |
|
|
Ciprofloxacin
|
Fluoroquinolones |
DNA gyrase-catalyzed super-coiling of double-stranded DNA |
Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA) |
Oral |
|
Sitafloxacin
|
Fluoroquinolones |
Bacterial DNA gyrase (topoisomerase II) |
Bacteriostatic (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA) |
Oral |
|
Moxifloxacin
|
Fluoroquinolones |
DNA gyrase |
Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA) |
Oral |
|
Ofloxacin
|
Quinolone |
DNA gyrase |
Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA) |
Oral |
|
Prulifloxacin
|
Quinolone |
DNA gyrase |
Bactericidal activity (They impede DNA replication and transcription by hindering the DNA gyrase-catalyzed super-coiling of double-stranded DNA) |
Oral |
|
Sparfloxacin
|
Quinolone |
DNA gyrase |
Bactericidal activity |
|
|
Dapsone
|
Sulfone |
|
Bactericidal activity (An imidazopyridine amide drug that targets the mycobacterial cytochrome bcc-aa3 terminal oxidase) |
|
|
Rifalazil
|
Benzoxazinorifamycin |
|
Bactericidal activity |
Oral |
|
Epiroprim
|
|
|
Bactericidal activity (inhibits dihydrofolate reductase) |
Injectable |
|
Ivermectins
|
Avermectins |
|
Bactericidal activity ( Inhibits the growth and also kill Mycobacterium ulcerans strains) |
Oral |
|
Milbemycin oxime and selamectin
|
Avermectins and milbemycins |
|
Bactericidal activity (in vitro pharmacodynamic studies demonstrates exposure-dependent activity of selamectin) |
Oral |
|
Imidazopyridine amine telacebec (Q203)
|
|
respiratory terminal oxidase cytochrome bc1:aa3 |
Bactericidal activity |
Oral |
|
Moxifloxacin, R207910 and linezolid
|
|
topoisomerase II (DNA gyrase) and topoisomerase IV |
Bactericidal activity |
Oral |
|
Q203 (Telacebec)
|
|
cytochrome bcc-aa3 terminal oxidase |
Bactericidal activity |
Oral |
|
Clofazimine
|
Riminophenazine |
|
Bactericidal activity |
Oral |
|
Bedaquiline
|
Diarylquinoline |
|
Bactericidal activity |
Oral |
|
Rifapentine
|
Rifamycin |
|
Bactericidal activity |
Oral |
|
Pretomanid (PA-824)
|
Nitroimidazopyran |
|
Bactericidal activity |
|
|
Mathesia
|
Phytomedicine |
|
|
|
