Drug Target

Gene Name Organism Gene Symbol Gene ID Target ID Associated Metabolic Pathways Function
Polyphosphate glucokinase Mycobacterium ulcerans (strain Agy99) ppgk 4553175 953626 Glycolysis/Gluconeogenesis and Amino sugar and nucleotide sugar metabolism Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor (PubMed: 8617763). Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme.
Fructose 1,6-bisphosphatase II Mycobacterium ulcerans (strain Agy99) glpX 4553973 952774 Glycolysis/Gluconeogenesis Pentose phosphate pathway , Fructose and mannose metabolism Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate (PubMed:15470127, PubMed:21451980). Seems to be the major FBPase of M. ulcerans and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans
Fructose-bisphosphate aldolase Mycobacterium ulcerans (strain Agy99) fba 4551433 953187 Glycolysis/Gluconeogenesis, Pentose phosphate pathway , Fructose and mannose metabolism and methane metabolism Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Pyruvate dehydrogenase subunit E1 Mycobacterium ulcerans (strain Agy99) aceE 4550721 951543 Glycolysis/Gluconeogenesis, Citrate cycle (TCA cycle), Valine, leucine and isoleucine biosynthesis, Pyruvate metabolism and Butanoate metabolism The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
2-oxoglutarate ferredoxin oxidoreductase subunit beta Mycobacterium ulcerans (strain Agy99) porB 4552934 951782 Citrate cycle (TCA cycle) Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Isocitrate dehydrogenase [NADP] Mycobacterium ulcerans (strain Agy99) icd2 4551485 953811 Citrate cycle (TCA cycle) and Glutathione metabolism Catalyzes the oxidative decarboxylation of isocitrate, resulting in alpha-ketoglutarate and carbon dioxide.
Tranketolase Mycobacterium ulcerans (strain Agy99) tkt 4551664 952493 Pentose phosphate pathway Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Ribose-5-phosphate isomerase B Mycobacterium ulcerans (strain Agy99) rpiB 4549706 952600 Pentose phosphate pathway Involved in the Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.
UTP--glucose-1-phosphate uridylyltransferase Mycobacterium ulcerans (strain Agy99) galU 4554380 951862 Pentose and glucuronate interconversions, Galactose metabolism, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism Catalyzes the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
UDP-glucose 4-epimerase Mycobacterium ulcerans (strain Agy99) galE3 4551632 9516655 Galactose metabolism, Amino sugar and nucleotide sugar metabolism catalyzes the reversible conversion between UDP-galactose (UDP-Gal) and UDP-glucose (UDP-Glc) in the third step of the Leloir pathway in galactose metabolism.
Glucose-1-phosphate adenylyltransferase Mycobacterium ulcerans (strain Agy99) glgC 4549918 954310 Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
Alpha, alpha-trehalose-phosphate synthase [UDP-forming] Mycobacterium ulcerans (strain Agy99) otsA 4550106 951926 Starch and sucrose metabolism Probably involved in the osmoprotection via the biosynthesis of trehalose and in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Probably also able to use ADP-Glc, CDP-Glc, GDP-Glc and TDP-Glc as glucosyl donors.
4-alpha-glucanotransferase Mycobacterium ulcerans (strain Agy99) malQ 4553740 953359 Starch and sucrose metabolism It is an enzyme that catalyzes a chemical reaction that transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor carbohydrate, which may be glucose or a 1,4-alpha-D-glucan.
Bifunctional N-acetylglucosamiNe-1-phosphate Mycobacterium ulcerans (strain Agy99) glmU 4550808 952932 Amino sugar and nucleotide sugar metabolism Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Phosphoglucosamine mutase Mycobacterium ulcerans (strain Agy99) glmM 4553772 954097 Amino sugar and nucleotide sugar metabolism Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
U DP-N-acetylenolpyruvoylglucosamine reductase Mycobacterium ulcerans (strain Agy99) murB 4554005 952251 Amino sugar and nucleotide sugar metabolism and Peptidoglycan biosynthesis Cell wall formation.
2-isopropylmalate synthase Mycobacterium ulcerans (strain Agy99) leuA 4551109 954605 Valine, leucine and isoleucine biosynthesis and Pyruvate metabolism Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) Mycobacterium ulcerans (strain Agy99) accD3 4549645 954780 Fatty acid biosynthesis, Pyruvate metabolism and Propanoate metabolism Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Acetate kinase Mycobacterium ulcerans (strain Agy99) ackA 4552980 954592 Pyruvate metabolism, Taurine and hypotaurine metabolism, Propanoate metabolism and Methane metabolism Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Isopropylmalate isomerase large subunit Mycobacterium ulcerans (strain Agy99) leuC 4551188 952959 Valine, leucine and isoleucine biosynthesis and C5-Branched dibasic acid metabolism Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
NADH dehydrogenase subunit M Mycobacterium ulcerans (strain Agy99) NuoM 4550308 953353 Oxidative phosphorylation catalyzes the transfer of electrons from NADH to the quinone pool in the cytoplasmic membrane and is able to generate a proton electrochemical gradient. It is part of both the aerobic and anaerobic respiratory chain of the cell.
F0F1 ATP synthase subunit delta Mycobacterium ulcerans (strain Agy99) atpH 4552593 954088 Oxidative phosphorylation F1F0 ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core and F0 containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).
F0F1 ATP synthase subunit epsilon Mycobacterium ulcerans (strain Agy99) atpC 4552589 954112 Oxidative phosphorylation Produces ATP from ADP in the presence of a proton gradient across the membrane.
F0F1 ATP synthase subunit A Mycobacterium ulcerans (strain Agy99) atpB 4552596 954864 Oxidative phosphorylation Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Rieske iron-sulfur protein Mycobacterium ulcerans (strain Agy99) qcrA 4554548 Oxidative phosphorylation Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
Ubiquinol-cytochrome c reductase Mycobacterium ulcerans (strain Agy99) qcrB 4554549 952733 Oxidative phosphorylation Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
Ubiquinol-cytochrome c reductase Mycobacterium ulcerans (strain Agy99) qcrC 4554547 955065 Oxidative phosphorylation transfer electrons from quinols to cytochrome c, translocating protons across membranes in the process.
Transmembrane cytochrome c oxidase (subunit II) Mycobacterium ulcerans (strain Agy99) ctaC 4554553 953489 Oxidative phosphorylation Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Integral membrane cytochrome d ubiquinol oxidase (subunit II) Mycobacterium ulcerans (strain Agy99) cydB 4552126 955276 Oxidative phosphorylation Oxidoreductase activity
Catalase-peroxidase-peroxynitritase T Mycobacterium ulcerans (strain Agy99) katG 4550625 953341 Phenylalanine metabolism, Tryptophan metabolism and Methane metabolism Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Phosphoserine aminotransferase Mycobacterium ulcerans (strain Agy99) serC 4551603 954716 Glycine, serine and threonine metabolism, Methane metabolism and Vitamin B6 metabolism Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
L-aparaginase Mycobacterium ulcerans (strain Agy99) ansA 4552348 952392 Alanine, aspartate and glutamate metabolism, Cyanoamino acid metabolism and Nitrogen metabolism catalyzes asparagine into aspartate and ammonia, thereby inhibiting protein synthesis.
Ferredoxin-dependent nitrite reductase Mycobacterium ulcerans (strain Agy99) nirA_2 4553115 955519 Nitrogen metabolism Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.
Cyanate hydratase Mycobacterium ulcerans (strain Agy99) cynS 4553839 953708 Nitrogen metabolism Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
Serine acetyltransferase Mycobacterium ulcerans (strain Agy99) cysE 4552462 952065 Cysteine and methionine metabolism and Sulfur metabolism catalyzes the activation of L-serine by acetyl-CoA.
Phosphoadenosine phosphosulfate reductase Mycobacterium ulcerans (strain Agy99) cysH_1 4549696 951764 Sulfur metabolism Reduction of activated sulfate into sulfite.
Homoserine O-acetyltransferase Mycobacterium ulcerans (strain Agy99) metX 4552501 952078 Cysteine and methionine metabolism and Sulfur metabolism Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Fatty acid synthase Mycobacterium ulcerans (strain Agy99) fas 4554262 952195 Fatty acid biosynthesis key enzyme that regulates the de novo biosynthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA in the presence of NADPH.
3-oxoacyl-[acyl-carrier-protein] synthase III Mycobacterium ulcerans (strain Agy99) fabH_1 4553928 955685 Fatty acid biosynthesis Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Acyl-[acyl-carrier protein] desaturase Mycobacterium ulcerans (strain Agy99) desA2 4553980 954910 Fatty acid biosynthesis and Biosynthesis of unsaturated fatty acids May be a desaturase involved in mycobacterial fatty acid biosynthesis.
Glycerol-3-phosphate acyltransferase Mycobacterium ulcerans (strain Agy99) plsB1 4552359 954287 Glycerolipid metabolism and Glycerophospholipid metabolism It catalyzes the conversion of glycerol-3-phosphate and long-chain acyl-CoA to lysophosphatidic acid
Ribonucleotide-diphosphate reductase subunit alpha Mycobacterium ulcerans (strain Agy99) NrdE 4551548 953732 Purine metabolism and Pyrimidine metabolism Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Urease subunit alpha Mycobacterium ulcerans (strain Agy99) ureC 4553657 952057 Purine metabolism, Arginine and proline metabolism and Atrazine degradation enzyme that catalyzes the hydrolysis of urea, forming ammonia and carbon dioxide
FAD-dependent thymidylate synthase Mycobacterium ulcerans (strain Agy99) thyX 4550652 953722 Pyrimidine metabolism and One carbon pool by folate Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH2 as the reductant.
Cytidylate kinase Mycobacterium ulcerans (strain Agy99) cmk 4554210 951979 Pyrimidine metabolism catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation of nucleoside diphosphates.
Uridylate kinase Mycobacterium ulcerans (strain Agy99) pyrH 4551033 952936 Pyrimidine metabolism Catalyzes the reversible phosphorylation of UMP to UDP.
L-serine dehydratase Mycobacterium ulcerans (strain Agy99) sdaA 4554185 953311 Glycine, serine and threonine metabolism, Cysteine and methionine metabolism functions mainly to provide a substrate, pyruvate, for gluconeogenesis to form glucose from amino acids.
Tryptophan synthase subunit beta Mycobacterium ulcerans (strain Agy99) trpB 4552115 953497 Glycine, serine and threonine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Homoserine kinase Mycobacterium ulcerans (strain Agy99) thrB 4552604 955040 Glycine, serine and threonine metabolism Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Homoserine dehydrogenase Mycobacterium ulcerans (strain Agy99) thrA 4551394 952581 Glycine, serine and threonine metabolism, Cysteine and methionine metabolism and Lysine biosynthesis catalyzes the reaction of aspartate-semialdehyde (ASA) to homoserine. The overall reaction reduces the C4 carboxylic acid functional group of ASA to a primary alcohol and oxidizes the C1 aldehyde to a carboxylic acid.
Aspartate-semialdehyde dehydrogenase Mycobacterium ulcerans (strain Agy99) asd 4551105 955348 Glycine, serine and threonine metabolism, Cysteine and methionine metabolism and Lysine biosynthesis Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Aspartate kinase Mycobacterium ulcerans (strain Agy99) ask 4551106 954273 Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Lysine biosynthesis Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase  (EC:2.1.1.14) Mycobacterium ulcerans (strain Agy99) metE 4552861 954807 Cysteine and methionine metabolism and Selenocompound metabolism Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Bifunctional Mta/Sah Nucleosidase Mycobacterium ulcerans (strain Agy99) mtn 4549626 954706 Cysteine and methionine metabolism This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route).
ketol-acid reductoisomerase Mycobacterium ulcerans (strain Agy99) ilvC 4551257 953094 Valine, leucine and isoleucine biosynthesis, Pantothenate and CoA biosynthesis Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Dihydroxy-acid dehydratase Mycobacterium ulcerans (strain Agy99) ilvD 4553233 955234 Valine, leucine and isoleucine biosynthesis catalyzes the chemical reaction of 2,3-dihydroxy-3-methylbutanoate to produce 3-methyl-2-oxobutanoate + H2O
Dihydrodipicolinate synthase Mycobacterium ulcerans (strain Agy99) dapA_1 4551835 954900 Pantothenate and CoA biosynthesis, and Lysine biosynthesis catalyzes the first unique step of lysine biosynthesis
UDP-N-acetylmuramoylalaNyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase Mycobacterium ulcerans (strain Agy99) murF 4550976 952109 Lysine biosynthesis and Peptidoglycan biosynthesis Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Transferase Mycobacterium ulcerans (strain Agy99) dapD 952056 Lysine biosynthesis Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC:6.3.2.13) Mycobacterium ulcerans (strain Agy99) murE 4550977 952901 Lysine biosynthesis and Peptidoglycan biosynthesis Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Succinyl-diaminopimelate desuccinylase Mycobacterium ulcerans (strain Agy99) dapE 4552203 955478 Lysine biosynthesis involved in the biosynthesis of diaminopimelic acid which is the precursor of meso-DAP, an essential component of peptidoglycan.
Diaminopimelate epimerase Mycobacterium ulcerans (strain Agy99) dapF 4553492 951992 Lysine biosynthesis Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Diaminopimelate decarboxylase Mycobacterium ulcerans (strain Agy99) lysA 4551395 953906 Lysine biosynthesis Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Acetylglutamate kinase Mycobacterium ulcerans (strain Agy99) argB 4552059 952664 Lysine biosynthesis, Arginine and proline metabolism Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
N-acetyl-gamma-glutamyl-phosphate reductase Mycobacterium ulcerans (strain Agy99) argC 4552057 953100 Lysine biosynthesis, Arginine and proline metabolism Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Mycobacterium ulcerans (strain Agy99) argJ 4552058 953205 Arginine and proline metabolism Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.
Proline dehydrogenase Mycobacterium ulcerans (strain Agy99) putA 4552184 955287 Arginine and proline metabolism initiator of the proline cycle.
ATP phosphoribosyltransferase Mycobacterium ulcerans (strain Agy99) hisG 4550462 954508 Histidine metabolism Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Imidazole glycerol phosphate synthase subunit Mycobacterium ulcerans (strain Agy99) hisF 4552314 952797 Histidine metabolism IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Imidazole glycerol phosphate synthase subunit Mycobacterium ulcerans (strain Agy99) hisH 4552311 955227 Histidine metabolism IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
Phosphoribosyl-AMP cyclohydrolase Mycobacterium ulcerans (strain Agy99) hisI 4552315 953103 Histidine metabolism Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Imidazoleglycerol-phosphate dehydratase Mycobacterium ulcerans (strain Agy99) hisB 4552310 951490 Histidine metabolism catalyzes the sixth step in the histidine biosynthesis pathway, the dehydration of imidazoleglycerol-phosphate (IGP) to form imidazoleacetol-phosphate (IAP).
Aminotransferase Mycobacterium ulcerans (strain Agy99) cobC 4551383 953318 Histidine metabolism, Tyrosine metabolism, Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis and Novobiocin biosynthesis catalyze the interconversion of amino acids and oxoacids by transfer of amino groups.
Histidinol dehydrogenase Mycobacterium ulcerans (strain Agy99) hisD 4552308 952567 Histidine metabolism Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase Mycobacterium ulcerans (strain Agy99) aroG_1 4553930 952014 Phenylalanine, tyrosine and tryptophan biosynthesis Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
3-dehydroquinate synthase Mycobacterium ulcerans (strain Agy99) aroB 4551800 955294 Phenylalanine, tyrosine and tryptophan biosynthesis Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
3-dehydroquinate dehydratase Mycobacterium ulcerans (strain Agy99) aroD 4551801 952923 Phenylalanine, tyrosine and tryptophan biosynthesis Catalyzes a trans-dehydration via an enolate intermediate.
Shikimate 5-dehydrogenase Mycobacterium ulcerans (strain Agy99) aroE 4551796 952977 Phenylalanine, tyrosine and tryptophan biosynthesis Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.
Indole-3-glycerol-phosphate synthase Mycobacterium ulcerans (strain Agy99) trpC 4552114 953765 Phenylalanine, tyrosine and tryptophan biosynthesis Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
Phosphoribosyl isomerase A Mycobacterium ulcerans (strain Agy99) hisA 4552312 953074 Histidine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CDRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O.
Chorismate synthase Mycobacterium ulcerans (strain Agy99) aroC 954695 Phenylalanine, tyrosine and tryptophan biosynthesis Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Anthranilate phosphoribosyltransferase Mycobacterium ulcerans (strain Agy99) trpD 4554545 954565 Phenylalanine, tyrosine and tryptophan biosynthesis Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Anthranilate synthase component I Mycobacterium ulcerans (strain Agy99) trpE 4552112 954582 Phenylalanine, tyrosine and tryptophan biosynthesis Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Prephenate dehydratase Mycobacterium ulcerans (strain Agy99) pheA 4552407 953072 Phenylalanine, tyrosine and tryptophan biosynthesis catalyzes the oxidative decarboxylation of prephenate to 4-hydroxyphenylpyruvate (HPP) in the presence of NAD+
Aspartate alpha-decarboxylase Mycobacterium ulcerans (strain Agy99) panD 4549748 951955 beta-Alanine metabolism,Pantothenate and CoA biosynthesis Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Pantoate--beta-alanine ligase /Pantothenate synthetase Mycobacterium ulcerans (strain Agy99) panC 4549749 955268 beta-Alanine metabolism, Pantothenate and CoA biosynthesis Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Taurine catabolism dioxygenase Mycobacterium ulcerans (strain Agy99) tauD 4550787 952723 Taurine and hypotaurine metabolism Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.
UDP-N-acetylmuramate--L-alanine ligase Mycobacterium ulcerans (strain Agy99) murC 4550971 955296 D-Glutamine and D-glutamate metabolism and Peptidoglycan biosynthesis Cell wall formation.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase Mycobacterium ulcerans (strain Agy99) murD 4550974 953735 D-Glutamine and D-glutamate metabolism and Peptidoglycan biosynthesis Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Alanine racemase Mycobacterium ulcerans (strain Agy99) alr 4550853 953776 D-Alanine metabolism a Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
D-alanyl-alanine synthetase A Mycobacterium ulcerans (strain Agy99) ddl 4551195 954296 D-Alanine metabolism and Peptidoglycan biosynthesis Cell wall formation.
Phospho-N-acetylmuramoyl-pentapeptide-transferase Mycobacterium ulcerans (strain Agy99) mraY 4550975 951592 Peptidoglycan biosynthesis a Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
UNdecaprenyl pyrophosphate phosphatase Mycobacterium ulcerans (strain Agy99) uppP 954139 Peptidoglycan biosynthesis a Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Penicillin-binding protein Mycobacterium ulcerans (strain Agy99) dacC 4552475 953802 Peptidoglycan biosynthesis a polymerize and modify peptidoglycan, the stress-bearing component of the bacterial cell wall.
Conserved Transmembrane protein Mycobacterium ulcerans (strain Agy99) MUL_5063 4553144 952655 Peptidoglycan biosynthesis a Function as gateways to permit the transport of specific substances across the membrane.
Penicillin-binding membrane protein Mycobacterium ulcerans (strain Agy99) pbpB 4550979 953787 Peptidoglycan biosynthesis a Involved in the biosynthesis of peptidoglycan (PG), the main component of bacterial cell walls.
Thiamine biosynthesis protein Mycobacterium ulcerans (strain Agy99) thiC 4553301 952463 Thiamine metabolism Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Phosphomethylpyrimidine kinase Mycobacterium ulcerans (strain Agy99) thiD 4553300 952161 Thiamine metabolism Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Thiamine biosynthesis oxidoreductase Mycobacterium ulcerans (strain Agy99) thiO 4552973 951863 Thiamine metabolism Imvolved in oxidoreductase activity
Thiamine monophosphate kinase Mycobacterium ulcerans (strain Agy99) thiL 4551197 954507 Thiamine metabolism Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Thiazole synthase Mycobacterium ulcerans (strain Agy99) thiG 4552971 954829 Thiamine metabolism Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.
Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein (EC:3.5.4.25) Mycobacterium ulcerans (strain Agy99) ribA1 4553315 955283 Riboflavin metabolism Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Bifunctional riboflavin biosynthesis protein Mycobacterium ulcerans (strain Agy99) ribG 4551729 952795 Riboflavin metabolism Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
6,7-dimethyl-8-ribityllumazine synthase Mycobacterium ulcerans (strain Agy99) ribH 4551697 955374 Riboflavin metabolism Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Riboflavin synthase subunit alpha Mycobacterium ulcerans (strain Agy99) ribC 4551695 954418 Riboflavin metabolism Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+
Bifunctional Nicotinate-Nucleotide adenylyltransferase NadD Mycobacterium ulcerans (strain Agy99) NadD 4553054 954963 Nicotinate and nicotinamide metabolism Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Quinolinate synthetase Mycobacterium ulcerans (strain Agy99) NadA 4552304 953306 Nicotinate and nicotinamide metabolism Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
3-methyl-2-oxobutanoate hydroxymethyltransferase Mycobacterium ulcerans (strain Agy99) panB 4551392 952595 Pantothenate and CoA biosynthesis Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Pantothenate kinase Mycobacterium ulcerans (strain Agy99) coaA 4551412 952617 Pantothenate and CoA biosynthesis Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
Biotin synthase Mycobacterium ulcerans (strain Agy99) bioB 4552336 955551 Biotin metabolism Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
6-pyruvoyl tetrahydrobiopterin synthase Mycobacterium ulcerans (strain Agy99) MUL_1264 4552005 954325 Folate biosynthesis Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+
Dihydroneopterin aldolase Mycobacterium ulcerans (strain Agy99) folB 4549754 953240 Folate biosynthesis Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Dihydropteroate synthase 2 Mycobacterium ulcerans (strain Agy99) folP2 4552207 955665 Folate biosynthesis Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Dihydrofolate reductase Mycobacterium ulcerans (strain Agy99) dfrA 4550648 953668 One carbon pool by folate and Folate biosynthesis Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Uroporphyrin-III C-methyltransferase Mycobacterium ulcerans (strain Agy99) hemD 4554534 951596 Porphyrin and chlorophyll metabolism Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.
Ferrochelatase Mycobacterium ulcerans (strain Agy99) hemH 4552377 955070 Porphyrin and chlorophyll metabolism Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
Multifunctional enzyme siroheme synthase Mycobacterium ulcerans (strain Agy99) cysG 4550998 955109 Porphyrin and chlorophyll metabolism Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.
Glutamyl-tRNA reductase Mycobacterium ulcerans (strain Agy99) hemA 4554532 954120 Porphyrin and chlorophyll metabolism Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Bifunctional protein, CobI-CobJ fusion protein Mycobacterium ulcerans (strain Agy99) cobI 4550528 954005 Porphyrin and chlorophyll metabolism Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A.
Precorrin-4 C11-methyltransferase Mycobacterium ulcerans (strain Agy99) CobM 4550535 952962 Porphyrin and chlorophyll metabolism Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5.
Antibiotic ABC transporter transmembrane protein Mycobacterium ulcerans (strain Agy99) MUL_1857 4551564 955127 Porphyrin and chlorophyll metabolism, Oxidative phosphorylation and Two-component system Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
O-succinylbenzoate synthase Mycobacterium ulcerans (strain Agy99) menC 4551816 953641 Ubiquinone and other terpenoid-quinone biosynthesis Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Mycobacterium ulcerans (strain Agy99) ispD 4551582 953026 Terpenoid backbone biosynthesis Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Mycobacterium ulcerans (strain Agy99) ispE 4554495 953089 Terpenoid backbone biosynthesis Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Mycobacterium ulcerans (strain Agy99) ispF 4551861 955134 Terpenoid backbone biosynthesis Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Mycobacterium ulcerans (strain Agy99) ispG 4551010 951729 Terpenoid backbone biosynthesis Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
4-hydroxy-3-methylbut-2-enyl diphosphate reductase Mycobacterium ulcerans (strain Agy99) ispH 4552689 954756 Terpenoid backbone biosynthesis Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
DTDP-4-dehydrorhamnose 3,5-epimerase Mycobacterium ulcerans (strain Agy99) rmlC 4550191 954021 Streptomycin biosynthesis and Polyketide sugar unit biosynthesis Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
Salicylate synthase Mycobacterium ulcerans (strain Agy99) mbtI 4553169 952586 Biosynthesis of siderophore group nonribosomal peptides Catalysis of the reaction: chorismate = isochorismate.
Lysine-N-oxygenase Mycobacterium ulcerans (strain Agy99) mbtG 4553161 955269 Biosynthesis of siderophore group nonribosomal peptides Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+).
DNA-directed RNA polymerase subunit alpha Mycobacterium ulcerans (strain Agy99) rpoA 4553558 955651 Purine metabolism, Pyrimidine metabolism and RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DNA-directed RNA polymerase subunit omega Mycobacterium ulcerans (strain Agy99) rpoZ 4551713 952763 Purine metabolism, Pyrimidine metabolism and RNA polymerase Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
50S ribosomal protein L23 Mycobacterium ulcerans (strain Agy99) rplW 4551536 953203 Ribosome One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
50S ribosomal protein L22 Mycobacterium ulcerans (strain Agy99) rplV 4551539 954722 Ribosome This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
30S ribosomal protein S3 Mycobacterium ulcerans (strain Agy99) rpsC 4551540 952363 Ribosome Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
30S ribosomal protein S17 Mycobacterium ulcerans (strain Agy99) rpsQ 4551543 952271 Ribosome One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
30S ribosomal protein S8 Mycobacterium ulcerans (strain Agy99) rpsH 4551345 952009 Ribosome One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
50S ribosomal protein L6 Mycobacterium ulcerans (strain Agy99) rplF 4551346 954258 Ribosome This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
50S ribosomal protein L18 Mycobacterium ulcerans (strain Agy99) rplR 4551347 953663 Ribosome This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
50S ribosomal protein L15 Mycobacterium ulcerans (strain Agy99) rplO 4551350 955300 Ribosome Binds to the 23S rRNA.
30S ribosomal protein S13 Mycobacterium ulcerans (strain Agy99) rpsM 4553555 951492 Ribosome Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
50S ribosomal protein L10 Mycobacterium ulcerans (strain Agy99) rplJ 4552140 954385 Ribosome Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
50S ribosomal protein L1 Mycobacterium ulcerans (strain Agy99) rplA 4552585 954723 Ribosome Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
30S ribosomal protein S2 Mycobacterium ulcerans (strain Agy99) rpsB 4551026 952776 Ribosome contributes to the structural integrity of the ribosome
50S ribosomal protein L21 Mycobacterium ulcerans (strain Agy99) rplU 4553007 951755 Ribosome This protein binds to 23S rRNA in the presence of protein L20.
Preprotein translocase subunit Mycobacterium ulcerans (strain Agy99) secY 4550180 951565 Protein export and Bacterial secretion system The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Preprotein translocase subunit Mycobacterium ulcerans (strain Agy99) secE 4552582 955541 Protein export and Bacterial secretion system Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Putative inner membrane protein translocase component Mycobacterium ulcerans (strain Agy99) MUL_5074 4551658 955218 Protein export and Bacterial secretion system Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Preprotein translocase subunit Mycobacterium ulcerans (strain Agy99) secA1 4550029 952820 Protein export and Bacterial secretion system Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Sec-independent protein translocase transmembrane protein T Mycobacterium ulcerans (strain Agy99) tatC 4550470 951653 Protein export and Bacterial secretion system Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
Lipoprotein signal peptidase Mycobacterium ulcerans (strain Agy99) lspA 4552349 954823 Protein export This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Proteasome (alpha subunit) Mycobacterium ulcerans (strain Agy99) prcA 4550475 952702 Proteasome Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Ribonuclease E Mycobacterium ulcerans (strain Agy99) rne 4553008 952584 RNA degradation Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
Transcription termination factor Mycobacterium ulcerans (strain Agy99) rho 4552603 952883 RNA degradation Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
DNA polymerase III subunit alpha Mycobacterium ulcerans (strain Agy99) dnaE1 886392 955558 Purine metabolism,Pyrimidine metabolism, DNA replication, Mismatch repair and Homologous recombination Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA polymerase III subunits gamma and tau Mycobacterium ulcerans (strain Agy99) dnaZX 4551318 954557 Purine metabolism, Pyrimidine metabolism, DNA replication, Mismatch repair and Homologous recombination DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
DNA polymerase III subunit delta Mycobacterium ulcerans (strain Agy99) MUL_4220 4551231 954682 Purine metabolism, Pyrimidine metabolism, DNA replication, Mismatch repair and Homologous recombination Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
Replicative DNA helicase Mycobacterium ulcerans (strain Agy99) dnaB 4551753 952976 DNA replication Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.
DNA primase Mycobacterium ulcerans (strain Agy99) dnaG 4552457 954275 DNA replication RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Excinuclease ABC subunit C Mycobacterium ulcerans (strain Agy99) uvrC 4551701 955512 Nucleotide excision repair The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Transcription-repair coupling factor Mycobacterium ulcerans (strain Agy99) mfd 4550805 952846 Nucleotide excision repair Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Recombinase A Mycobacterium ulcerans (strain Agy99) recA 4551966 954690 Homologous recombination Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
Holliday junction DNA helicase Mycobacterium ulcerans (strain Agy99) ruvA 4551864 951700 Homologous recombination The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
ATP-dependent DNA helicase Mycobacterium ulcerans (strain Agy99) recG 4551166 951514 Homologous recombination Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).
Sulfate-binding lipoprotein Mycobacterium ulcerans (strain Agy99) subI 4553123 953179 ABC transporters Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).
Sulfate-transport integral membrane protein ABC transporter Mycobacterium ulcerans (strain Agy99) cysT 4553122 952683 ABC transporters Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
Sulfate-transport integral membrane protein ABC transporter Mycobacterium ulcerans (strain Agy99) cysW 4553121 952411 ABC transporters Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
Molybdate-binding lipoprotein Mycobacterium ulcerans (strain Agy99) modA 4553650 954996 ABC transporters Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
Oligopeptide-transport integral membrane protein ABC transporter Mycobacterium ulcerans (strain Agy99) oppC 4550740 951897 ABC transporters Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
Hypothetical protein Mycobacterium ulcerans (strain Agy99) MUL_1240 4554510 954135 ABC transporters Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
Cell division protein Mycobacterium ulcerans (strain Agy99) ftsX 4550382 955204 ABC transporters involved in cell division
O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter Mycobacterium ulcerans (strain Agy99) RfbD 4549583 952229 ABC transporters involved in O-antigen/lipopolysaccharides (LPS) transport
Phosphate-binding protein 3 precursor Mycobacterium ulcerans (strain Agy99) phoS3 4549976 953515 ABC transporters Part of the ABC transporter complex PstSACB involved in phosphate import.
30S ribosomal protein S10 Mycobacterium ulcerans (strain Agy99) rpsJ 4551533 954787 Ribosome Involved in the binding of tRNA to the ribosomes.
Two component sensory transduction protein Mycobacterium ulcerans (strain Agy99) regX3 4554013 951531 Two-component systema Involved in DNA binding
Nitrate/Nitrite response regulator protein Mycobacterium ulcerans (strain Agy99) NarL 4550882 955054 Two-component system This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.
Chromosomal replication initiation protein Mycobacterium ulcerans (strain Agy99) dnaA 4553245 955150 Two-component system Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
Two component response transcriptional regulatory protein Mycobacterium ulcerans (strain Agy99) prrA 4549939 951624 Two-component system Involved in DNA binding
Two component sensor histidine kinase Mycobacterium ulcerans (strain Agy99) devS 4550363 955652 Two-component system The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
Two component trascriptional regulatory protein Mycobacterium ulcerans (strain Agy99) devR 4550364 953080 Two-component system
Nitrogen regulatory protein P-II Mycobacterium ulcerans (strain Agy99) glnB 4551087 952045 Two-component system P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme.
Phosphoglucomutase Mycobacterium ulcerans (strain Agy99) pgmA 4553259 954250 Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Galactose metabolism, Purine metabolism, Starch and sucrose metabolism, Amino sugar and Nucleotide sugar metabolism and Streptomycin biosynthesis Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Sulfate adenylyltransferase subunit 2 Mycobacterium ulcerans (strain Agy99) cysD 4550736 954451 Purine metabolism, Selenocompound metabolism and Sulfur metabolism Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.
Carbonic anhydrase Mycobacterium ulcerans (strain Agy99) MUL_3998 4550738 952661 Nitrogen metabolism catalyzes the conversion of carbon dioxide into a proton and the bicarbonate ion (HCO3-).
Tryptophan synthase subunit alpha Mycobacterium ulcerans (strain Agy99) trpA 4552116 955315 Glycine, serine and threonine metabolism , Phenylalanine, tyrosine and tryptophan biosynthesis The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexeNe-1-carboxylate synthase Mycobacterium ulcerans (strain Agy99) menD 4551818 954868 Ubiquinone and other terpenoid-quinone biosynthesis Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
Inorganic polyphosphate/ATP-NAD kinase Mycobacterium ulcerans (strain Agy99) ppnK 4551918 954860 Nicotinate and Nicotinamide metabolism Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
NAD synthetase Mycobacterium ulcerans (strain Agy99) NadE 4553066 951885 Nicotinate and Nicotinamide metabolism Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
1-deoxy-D-xylulose 5-phosphate reductoisomerase Mycobacterium ulcerans (strain Agy99) dxr 4551008 952059 Terpenoid backbone biosynthesis Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Poly(a) polymerase Mycobacterium ulcerans (strain Agy99) pcnA 4553141 955033 RNA degradation Involved in nucleic acid metabolism as a component of the replication and repair machinery
Arginyl-tRNA synthetase Mycobacterium ulcerans (strain Agy99) argS 4551396 952058 Aminoacyl-tRNA biosynthesis catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction Interpro ID: IPR001278
Histidyl-tRNA synthetase Mycobacterium ulcerans (strain Agy99) hisS 4551828 953676 Aminoacyl-tRNA biosynthesis
Phenylalanyl-tRNA synthetase subunit alpha Mycobacterium ulcerans (strain Agy99) pheS 954196 Aminoacyl-tRNA biosynthesis
Branched-chain alpha-keto acid dehydrogenase subunit E2 Mycobacterium ulcerans (strain Agy99) pdh 955470 Glycolysis/Gluconeogenesis, Citrate cycle (TCA cycle) and Pyruvate metabolism
Type II citrate synthase Mycobacterium ulcerans (strain Agy99) gltA 4549946 953216 Citrate cycle (TCA cycle) ,Glyoxylate and dicarboxylate metabolism
UDP-N-acetylglucosamine 1-carboxyvinyltransferase Mycobacterium ulcerans (strain Agy99) murA 4552517 952622 Amino sugar and nucleotide sugar metabolism and Peptidoglycan biosynthesis Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
4-aminobutyrate aminotransferase Mycobacterium ulcerans (strain Agy99) gabT 4551872 954173 Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Propanoate metabolism and Butanoate metabolism
Inorganic pyrophosphatase Mycobacterium ulcerans (strain Agy99) ppa 4550919 952539 Oxidative phosphorylation Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
D-3-phosphoglycerate dehydrogenase Mycobacterium ulcerans (strain Agy99) serA2 4550175 951598 Glycine, serine and threonine metabolism and Methane metabolism
Phosphoserine phosphatase Mycobacterium ulcerans (strain Agy99) serB 4551153 952993 Glycine, serine and threonine metabolism and Methane metabolism
Asparagine synthetase Mycobacterium ulcerans (strain Agy99) asnB 4554554 953806 Alanine, aspartate and glutamate metabolism and Nitrogen metabolism
Glutamine synthetase Mycobacterium ulcerans (strain Agy99) glnA2 4554075 952462 Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Nitrogen metabolism and Two-component system Catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine
Glutamate synthase subunit beta Mycobacterium ulcerans (strain Agy99) gltD 4549668 952166 Alanine, aspartate and glutamate metabolism and Nitrogen metabolism
1-acylglycerol-3-phosphate O-acyltransferase Mycobacterium ulcerans (strain Agy99) MUL_3537 4553934 952188 Glycerolipid metabolism and Glycerophospholipid metabolism
Flavoprotein Mycobacterium ulcerans (strain Agy99) MUL_1298 4550711 954232 Ether lipid metabolism
DNA-directed RNA polymerase subunit beta Mycobacterium ulcerans (strain Agy99) rpoB 4552145 954361 Purine metabolism, Pyrimidine metabolism and RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Phosphoribosylaminoimidazole-succinocarboxamide synthase Mycobacterium ulcerans (strain Agy99) purC 4551991 951845 Purine metabolism
Putative deoxyribonucleotide triphosphate pyrophosphatase Mycobacterium ulcerans (strain Agy99) MUL_3906 4553722 952902 Purine metabolism and Thiamine metabolism Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Dihydroorotase Mycobacterium ulcerans (strain Agy99) pyrC 4551744 951504 Pyrimidine metabolism Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Thioredoxin reductase Mycobacterium ulcerans (strain Agy99) trxB2 4553147 954857 Pyrimidine metabolism and Selenocompound metabolism
Aminotransferase AlaT Mycobacterium ulcerans (strain Agy99) aspC 4552732 954983 Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine biosynthesis
4-aminobutyrate aminotransferase Mycobacterium ulcerans (strain Agy99) gabT_2 4551477 954844 Glycine, serine and threonine metabolism
Gamma-glutamyl kinase Mycobacterium ulcerans (strain Agy99) proB 4553004 954245 Arginine and proline metabolism Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Shikimate kinase Mycobacterium ulcerans (strain Agy99) aroK 4551799 955526 Phenylalanine, tyrosine and tryptophan biosynthesis Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
6-phosphogluconate dehydrogenase-like protein Mycobacterium ulcerans (strain Agy99) gnd2 4552871 953282 Pentose phosphate pathway and Glutathione metabolism
Transaldolase Mycobacterium ulcerans (strain Agy99) tal 4551663 953718 Pentose phosphate pathway Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Succinic semialdehyde dehydrogenase Mycobacterium ulcerans (strain Agy99) gabD1 4554025 953164 Alanine, aspartate and glutamate metabolism, Tyrosine metabolism and Butanoate metabolism Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium (By similarity).
Fatty oxidation protein Mycobacterium ulcerans (strain Agy99) fadB 4554363 954772 Fatty acid metabolism, Valine, leucine and isoleucine degradation, Geraniol degradation, Lysine degradation, Benzoate degradation, beta-Alanine metabolism, Propanoate metabolism, Butanoate metabolism, Limonene and pinene degradation and Caprolactam degrad
Succinate dehydrogenase flavoprotein subunit Mycobacterium ulcerans (strain Agy99) sdhA 4554045 953928 Citrate cycle (TCA cycle), Oxidative phosphorylation, Toluene degradation and Butanoate metabolism
F0F1 ATP synthase subunit gamma Mycobacterium ulcerans (strain Agy99) atpG 4552591 953678 Oxidative phosphorylation Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF0 complex.
Cysteine synthase B Mycobacterium ulcerans (strain Agy99) cysM 4549648 952777 Cysteine and methionine metabolism and Sulfur metabolism
Glycine cleavage system aminomethyltransferase T Mycobacterium ulcerans (strain Agy99) gcvT 4553405 951787 Glycine, serine and threonine metabolism, One carbon pool by folate, Nitrogen metabolism The glycine cleavage system catalyzes the degradation of glycine.
Acetyl-CoA acetyltransferase Mycobacterium ulcerans (strain Agy99) fadA6_3 4552219 953885 Fatty acid metabolism, Valine, leucine and isoleucine degradation, Geraniol degradation, Benzoate degradation, alpha-Linolenic acid metabolism and Ethylbenzene degradation
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Mycobacterium ulcerans (strain Agy99) gpdA1 4553390 954732 Glycerophospholipid metabolism
Hypoxanthine-guanine phosphoribosyltransferase Mycobacterium ulcerans (strain Agy99) hpt 4550915 953815 Purine metabolism
Phosphoribosylaminoimidazole carboxylase catalytic subunit Mycobacterium ulcerans (strain Agy99) purE 4549864 952798 Purine metabolism Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Adenylosuccinate lyase Mycobacterium ulcerans (strain Agy99) purB 4551984 952700 Purine metabolism , Alanine, aspartate and glutamate metabolism catalyzes two reactions in the de novo purine biosynthetic pathway.
GMP synthase Mycobacterium ulcerans (strain Agy99) guaA 4550796 952535 Purine metabolism Catalyzes the synthesis of GMP from XMP.
Adenylate kinase Mycobacterium ulcerans (strain Agy99) adk 4550181 Purine metabolism Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
L-aspartate oxidase Mycobacterium ulcerans (strain Agy99) nadB 4552305 952561 Alanine, aspartate and glutamate metabolism, Nicotinate and nicotinamide metabolism Catalyzes the oxidation of L-aspartate to iminoaspartate.
Threonine synthase Mycobacterium ulcerans (strain Agy99) thrC 4552605 954031 Glycine, serine and threonine metabolism and Vitamin B6 metabolism Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
O-acetylhomoserine aminocarboxypropyltransferase Mycobacterium ulcerans (strain Agy99) metC 4552502 952591 Cysteine and methionine metabolism
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase (EC:2.4.1.227) Mycobacterium ulcerans (strain Agy99) murG 4550972 952412 Peptidoglycan biosynthesis a Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Phosphopantetheine adenylyltransferase (EC:2.7.7.3) Mycobacterium ulcerans (strain Agy99) coaD 4551175 953214 Pantothenate and CoA biosynthesis Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Glutamate racemase (EC:5.1.1.3) Mycobacterium ulcerans (strain Agy99) murI 4553594 952427 D-Glutamine and D-glutamate metabolism Provides the (R)-glutamate required for cell wall biosynthesis.
Isocitrate lyase/ isocitrase Mycobacterium ulcerans (strain Agy99) icl 4549819 954656 Glyoxylate cycle The key enzyme of mycobacterium’s glyoxylate. This metabolic pathway enables the organism to make direct use of the intermediates of the tricarboxylic acid (TCA) cycle for gluconeogenesis and other biosynthetic processes essential for its survival and persistence
Iron dependent regulator Mycobacterium ulcerans (strain Agy99) IdeR 4553185 952757 Iron metabolism Ensures that an optimum amount of iron is taken in by the bacteria for growth
Cytochrome bc1 complex cytochrome b subunit Mycobacterium ulcerans (strain Agy99) qcrB 4554549 952733 It is an essential component of the respiratory electron transport chain required for ATP synthesis
Cystathionine gamma-synthase Mycobacterium ulcerans (strain Agy99) metB 4551424 954920 methionine synthesis key receptor involved in methionine synthesis
Type I modular polyketide synthase Mycobacterium ulcerans (strain Agy99) mlsA1 2846548 954920 Required for the Synthesis of the polyketide toxin mycolactone. Enhances the virulence of the Mycobacterium ulcerans. Blocks exocytosis by blood platelets and mast cells, Impaires wound healing processes Has immunosuppresive properties Inhibits phagocytic activities of white blood cells and kills neutrophils that are dispatched to infected cells.
Type I modular polyketide synthase Mycobacterium ulcerans (strain Agy99) mlsA2 2846549 955418 Required for the Synthesis of the polyketide toxin mycolactone. Enhances the virulence of the Mycobacterium ulcerans. Blocks exocytosis by blood platelets and mast cells, Impaires wound healing processes Has immunosuppressive properties Inhibits phagocytic activities of white blood cells and kills neutrophils that are dispatched to infected cells.
Type I modular polyketide synthase Mycobacterium ulcerans (strain Agy99) mlsB 2846550 951964 Required for the Synthesis of the polyketide toxin mycolactone. Enhances the virulence of the Mycobacterium ulcerans. Blocks exocytosis by blood platelets and mast cells, Impaires wound healing processes Has immunosuppresive properties Inhibits phagocytic activities of white blood cells and kills neutrophils that are dispatched to infected cells.
Conserved protein Mycobacterium ulcerans (strain Agy99) MUL_3720 4553013 955390
Phosphomannmutase/Phosphoglucomutase Mycobacterium ulcerans (strain Agy99) manB 4549878 952910 Glycolysis/Gluconeogenesis, Pentose phosphate pathway , Fructose and mannose metabolism, Galactose metabolism, Purine metabolism, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism and Streptomycin biosynthesis Catalyzes the chemical reaction alpha-D-mannose 1-phosphate to produce D-mannose 6-phosphate